(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

Base Information

Chemical Name:(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one
CAS No.:1053645-74-1
Molecular Formula:C₄₄H₅₁N₃O₇
Molecular Weight:733.905
Hs Code.:

Synonyms:(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

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Chemical Property of (4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

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Technology Process of (4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

There total 6 articles about (4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 10445-91-7
4-(Chloromethyl)pyridine

: 1054665-32-5
(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-[1,3]diazepan-2-one

: 1053645-74-1
(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

Guidance literature:: With sodium hydride; for 346h;
DOI:10.1021/jm9602571

Reference yield:

: 58917-85-4
N-(benzyloxycarbonyl)-D-phenylalaninol

: 1053645-74-1
(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) CH₂Cl₂, -70 deg C, 2 h

2: 55 percent / VCl₃*(THF)3, Zn / CH₂Cl₂

3: diisopropylethylamine / dimethylformamide / 48 h / 50 °C

4: H₂ / 10percent Pd/C / ethyl acetate; methanol

5: 1.) NaH / 1.) DMF, RT, 10 min, 2.) DMF, RT, 8 h

6: 31 percent / NaH / 346 h

With oxalyl dichloride; Vanadium (III) chloride-(tris-tetrahydrofuran); hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571

Reference yield:

: 63219-70-5
N-(benzyloxycarbonyl)-D-phenylalaninal

: 1053645-74-1
(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-bis-(2-methoxy-ethoxymethoxy)-1-naphthalen-2-ylmethyl-3-pyridin-4-ylmethyl-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / VCl₃*(THF)3, Zn / CH₂Cl₂

2: diisopropylethylamine / dimethylformamide / 48 h / 50 °C

3: H₂ / 10percent Pd/C / ethyl acetate; methanol

4: 1.) NaH / 1.) DMF, RT, 10 min, 2.) DMF, RT, 8 h

5: 31 percent / NaH / 346 h

With Vanadium (III) chloride-(tris-tetrahydrofuran); hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571