6-benzoyl-2,4-dimethoxypyrimidine

Base Information

• Chemical Name: 6-benzoyl-2,4-dimethoxypyrimidine
• CAS No.: 1335213-02-9
• Molecular Formula: C₁₃H₁₂N₂O₃
• Molecular Weight: 244.25
• Mol file: 1335213-02-9.mol

Synonyms:6-benzoyl-2,4-dimethoxypyrimidine

Chemical Property of 6-benzoyl-2,4-dimethoxypyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzoyl-2,4-dimethoxypyrimidine

There total 3 articles about 6-benzoyl-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 6-benzoyl-2,4-dimethoxypyrimidine (1335213-02-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 1h; Cooling with ice; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield: 63.0%

2,4-dimethoxypyrimidine (3551-55-1) + benzoyl chloride (98-88-4) → 6-benzoyl-2,4-dimethoxypyrimidine (1335213-02-9) + 2,4-dimethoxypyrimidin-5-yl(phenyl)ketone (1201670-60-1)

Guidance literature:

2,4-dimethoxypyrimidine; With n-butyllithium; CuCl₂*TMEDA; 2,2,6,6-tetramethylpiperidinyl-lithium; In hexanes; TMEDA, tetramethyl-ethylenediamine; toluene; at 20 ℃; for 2h; Inert atmosphere;

benzoyl chloride; In hexanes; TMEDA, tetramethyl-ethylenediamine; toluene; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201100990

Reference yield:

2,4-dimethoxy-6-(trimethylstannyl)pyrimidine (1032990-45-6) + benzoyl chloride (98-88-4) → 6-benzoyl-2,4-dimethoxypyrimidine (1335213-02-9)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In toluene; Heating;

DOI:10.1021/jo800358v

upstream raw materials:

2,4-dimethoxy-6-(trimethylstannyl)pyrimidine

benzoyl chloride

2,4-dimethoxypyrimidine

Downstream raw materials:

6-benzoyl uracil

Refernces

• 1、 Nguyen, Tan Tai,Marquise, Nada,Chevallier, Floris,Mongin, Florence. "Deprotonative metalation of aromatic compounds by using an amino-based lithium cuprate". experimental part. p. 10405 - 10416. Retrieved 2011/10/12.