3551-55-1

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dimethoxypyrimidine is used as a synthetic building block for the creation of various chemical compounds, particularly derivatives of Cytidine (C998300). Its role in the pharmaceutical industry is crucial for the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,4-Dimethoxypyrimidine is utilized as a key intermediate for the production of a wide range of chemical compounds. Its unique structure and properties make it a valuable component in the synthesis process, contributing to the development of novel materials and products.

InChI:InChI=1/C6H8N2O2/c1-9-5-3-4-7-6(8-5)10-2/h3-4H,1-2H3

Upstream product

• 18002-25-0 4-methoxy-2-pyrimidone 
• 77-78-1 dimethyl sulfate 
• 124-41-4 sodium methylate 
• 2802-61-1 2,4-difluoropyrimidine 
• 3934-20-1 2,6-Dichloropyrimidine 

Downstream Products

• 4603-96-7 4-methoxy-1-(tetra-O-acetyl-β-D-glucopyranosyl)-1H-pyrimidin-2-one 
• 15400-58-5 methyl 2,4-dimethoxypyrimidine-5-carboxylate 
• 80504-44-5 1,2-dihydro-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine 
• 83956-20-1 (O-benzyl-3-desoxy-4-α-DL-threo-pentopyranosyl)-1-methoxy-4-pyrimidinone-2 
• 83750-65-6 (O-benzyl-2-desoxy-4-β-DL-threo-pentopyranosyl)-1-methoxy-4-pyrimidinone-2 
• 83750-65-6 (O-benzyl-2-desoxy-4-α-DL-threo-pentopyranosyl)-1-methoxy-4-pyrimidinone-2 
• 83956-18-7 (O-benzoyl-3-desoxy-4-α-DL-threo-pentopyranosyl)-1-methoxy-4-pyrimidinone-2 
• 83956-19-8 (desoxy-4-O-p-nitrobenzoyl-3-α-DL-threo-pentopyranosyl)-1-methoxy-4-pyrimidinone-2 
• 83956-27-8 (tri-O-benzoyl-3,5,6-β-D-glucofuranosyl)-1-methoxy-4-pyrimidinone-2 
• 118174-13-3 4-O-methyl-1-(3,4,6-tri-O-benzyl-β-D-glucopyranosyl)-2-pyrimidinone 
• 52606-02-7 2,4-dimethoxy-5-pyrimidine carboxaldehyde 
• 5151-34-8 2,4-Dimethoxy-5-methylpyrimidine 
• 696-07-1 5-iodouracil 
• 52522-99-3 2,4-dimethoxy-5-iodopyrimidine 

Relevant academic research and scientific papers

HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives

The lithium salts of the conjugated bases of 4-methoxy- and 4-acetylamino-2(1H)-pyrimidinones 1-3 undergo highly chemoselective N1-methylation or ethylation when treated with methyl- or ethylsulfate (hard electrophiles) in dry dioxane, while the use of DMF as solvent results in competitive O2-alkylation. Potassium salts of the same bases in DMF undergo prevalent O2-attack. Under the same conditions, a similar but less chemoselective behaviour is observed in alkylation of thymine and uracil, where some N3-attack occurs. This can be rationalised in terms of the HSAB principle.

Fluorinated Heterocyclic Compounds. 2. 2,4-Difluoro and 4-Amino-2-fluoropyrimidines, Nucleoside Base Analogs

Nucleoside base analogs in which fluoro substituents replace the enolic hydroxy groups of uracil, thymine and cytosine have been prepared.Improved methods for the preparation and isolation of the known 2,4-difluoropyrimidine, 2,4-difluoro-6-methylpyrimidine and the new 2,4-difluoro-5-methylpyrimidine, 2-fluoro-4-aminopyrimidine, 4-fluoro-2-aminopyrimidine, and other alkylaminofluoropyrimidines are described.