2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233249-38-1
Molecular Formula:C₂₄H₂₄N₂O₅
Molecular Weight:420.465
Hs Code.:

Synonyms:2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

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Technology Process of 2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

There total 11 articles about 2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1233249-37-0
1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 1233249-38-1
2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid; With oxalyl dichloride; In chloroform; at 20 ℃; for 3.5h; Cooling with ice;

diazomethyl-trimethyl-silane; In tetrahydrofuran; acetonitrile; for 2h; Cooling with ice;

methanol;

Reference yield:

: 1233246-59-7
[1-({4-[(tert-butoxycarbonyl)amino]phenyl}carbonyl)isoquinolin-4-yl] acetic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 1233249-38-1
2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1233249-38-1
2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 - 35 °C

4.1: oxalyl dichloride / chloroform / 3.5 h / 20 °C / Cooling with ice

4.2: 2 h / Cooling with ice

With oxalyl dichloride; water; sodium hexamethyldisilazane; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; chloroform;