2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

Base Information

Chemical Name:2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester
CAS No.:1430737-14-6
Molecular Formula:C₄₄H₄₁N₃O₇S
Molecular Weight:755.891
Hs Code.:

Synonyms:2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

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Chemical Property of 2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

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Technology Process of 2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

There total 6 articles about 2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1430737-12-4
tert-butyl-2-(6-(benzylamino)-4,7-dihydro-4,7-dioxo-1-tosyl-1H-indol-3-yl)ethylcarbamate

: 1430737-04-4
4-benzyloxyphenylacetaldehyde diethyl acetal

: 1430737-14-6
2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

Guidance literature:: With manganese triacetate; In acetonitrile; for 40h; Reflux;
DOI:10.1016/j.tet.2013.03.052

Reference yield:

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

: 1430737-14-6
2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 25 °C

2: sulfuric acid / 3 h / 25 °C / Dean-Stark

3: manganese triacetate / acetonitrile / 40 h / Reflux

With sulfuric acid; 2-iodoxybenzoic acid; manganese triacetate; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tet.2013.03.052

Reference yield:

: 501-94-0
p-hydroxyphenethyl alcohol

: 1430737-14-6
2-[7-benzyl-5-(4-benzyloxyphenyl)-4,8-dioxo-1-tosyl-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indol-3-yl]ethylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C

1.2: 4 h / 25 °C

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 25 °C

3.1: sulfuric acid / 3 h / 25 °C / Dean-Stark

4.1: manganese triacetate / acetonitrile / 40 h / Reflux

With sulfuric acid; 2-iodoxybenzoic acid; manganese triacetate; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2013.03.052