1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

Base Information

Chemical Name:1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine
CAS No.:335451-49-5
Molecular Formula:C₂₄H₃₄N₂O₃SSi
Molecular Weight:458.697
Hs Code.:

Synonyms:1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

Suppliers and Price of 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

Chemical Property:

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Technology Process of 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

There total 4 articles about 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 250672-50-5
1-(tert-butyldimethylsilyl)-3-bromo-5-methoxy-1H-indole

: 1-(4-Methylbenzenesulfonyl)aziridine

: 335451-49-5
1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

Guidance literature:: 1-(tert-butyldimethylsilyl)-3-bromo-5-methoxy-1H-indole; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.166667h;

With copper(I) bromide dimethylsulfide complex; In diethyl ether; pentane; at -78 ℃; for 0.25h;

1-(4-Methylbenzenesulfonyl)aziridine; With boron trifluoride diethyl etherate; In diethyl ether; pentane; at -78 ℃; for 4h;
DOI:10.1055/s-2001-10812

Reference yield:

: 1006-94-6
5-methoxylindole

: 335451-49-5
1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -10 °C

1.2: tetrahydrofuran; hexane / 3 h / 0 °C

2.1: 5.4 g / NBS / tetrahydrofuran; hexane / 3 h / -78 °C

3.1: t-BuLi / pentane; diethyl ether / 0.17 h / -78 °C

3.2: CuBr*SMe₂ / pentane; diethyl ether / 0.25 h / -78 °C

3.3: 50 percent / BF₃*Et₂O / pentane; diethyl ether / 4 h / -78 °C

With N-Bromosuccinimide; n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; hexane; pentane;
DOI:10.1055/s-2001-10812

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 335451-49-5
1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -10 °C

1.2: tetrahydrofuran; hexane / 3 h / 0 °C

2.1: 5.4 g / NBS / tetrahydrofuran; hexane / 3 h / -78 °C

3.1: t-BuLi / pentane; diethyl ether / 0.17 h / -78 °C

3.2: CuBr*SMe₂ / pentane; diethyl ether / 0.25 h / -78 °C

3.3: 50 percent / BF₃*Et₂O / pentane; diethyl ether / 4 h / -78 °C

With N-Bromosuccinimide; n-butyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; hexane; pentane;
DOI:10.1055/s-2001-10812