methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

Base Information

Chemical Name:methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate
CAS No.:1361109-96-7
Molecular Formula:C₂₉H₂₅ClN₄O₆S₂
Molecular Weight:625.126
Hs Code.:

Synonyms:methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

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Chemical Property of methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

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Technology Process of methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

There total 4 articles about methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1240518-04-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 1361109-96-7
methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 1361109-96-7
methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.33 h / Inert atmosphere

3.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C

4.2: 0.5 h

5.1: pyridine / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1361109-96-7
methyl 4-((3-((3-(5-chlorothiopene-2-sulfanamido)-4-methoxy-1H-indazol-1-yl)methyl)benzyl)carbamoyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C

3.2: 0.5 h

4.1: pyridine / 20 °C

With pyridine; lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;