N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

Base Information

Chemical Name:N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide
CAS No.:476305-25-6
Molecular Formula:C₄₃H₇₃NO₅Si₂
Molecular Weight:740.227
Hs Code.:

N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

Synonyms:N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

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Chemical Property of N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

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Technology Process of N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

There total 1 articles about N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 476468-68-5
lovastatin benzylamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 476305-25-6
N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

Guidance literature:: With 1H-imidazole; In DMF (N,N-dimethyl-formamide); at 60 - 65 ℃; for 4h;

Reference yield:

: 476305-25-6
N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

: 74-88-4
methyl iodide

: 476305-26-7
N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2,2-dimethylbutanoyl]oxy]-1(S)naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide

Guidance literature:: N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide; With pyrrolidine; n-butyllithium; In tetrahydrofuran; hexanes; at -40 - -30 ℃; for 2.16667h;

methyl iodide; In tetrahydrofuran; hexanes; at -30 - -10 ℃; for 2h;