2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine

Base Information

• Chemical Name: 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine
• CAS No.: 107812-63-5
• Molecular Formula: C₁₈H₁₉ClN₂O₆
• Molecular Weight: 394.812

Synonyms:2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine

Chemical Property of 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine

There total 8 articles about 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

ethyl 2-(3-nitrobenzylidene)-4-chloro-3-oxobutanoate (104537-70-4) + methyl 3-aminocrotonate (14205-39-1) → 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine (107812-63-5)

Guidance literature:

at 85 ℃; for 2h; Ionic liquid;

Reference yield: 27.0%

ethyl (2-chloroaceto)acetate (638-07-3) + 3-nitro-benzaldehyde (99-61-6) + methyl (E)-3-aminocrotonate (14205-39-1) → 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine (107812-63-5) + methyl 2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydro-furo<3,4-b>pyridine-3-carboxylate (88250-01-5)

Guidance literature:

In ethanol; at 47 ℃; for 6h;

DOI:10.1002/ardp.19973300804

Reference yield:

4-chloro-2-ethoxycarbonyl-1-(3-nitro-phenyl)-but-1-en-3-one + methyl 3-aminocrotonate (21731-17-9) → 2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitro-phenyl)-6-methyl-1,4-dihydropyridine (107812-63-5)

Guidance literature:

In diethyl ether; ethanol; ethyl acetate;

upstream raw materials:

(3S,4R)-2-[1-Chloro-meth-(Z)-ylidene]-6-methyl-4-(3-nitro-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

ethyl (2-chloroaceto)acetate

3-nitro-benzaldehyde

methyl (E)-3-aminocrotonate

Downstream raw materials:

2-Imidazol-1-ylmethyl-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

2-chloromethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitrophenyl)-6-methylpyridine

methyl 2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydro-furo<3,4-b>pyridine-3-carboxylate

2-phenylselenylmethyl-3-carboethoxy-5-carbomethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine

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