6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

Base Information

Chemical Name:6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid
CAS No.:304443-32-1
Molecular Formula:C₁₃H₁₄N₂O₃
Molecular Weight:246.266
Hs Code.:

Synonyms:6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

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Chemical Property of 6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

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Technology Process of 6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

There total 1 articles about 6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

: 328-42-7
Oxalacetic acid

: 5779-95-3
3,5-dimethylbenzaldehyde

: 57-13-6
urea

: 304443-32-1
6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In 1,2-dichloro-ethane; for 12h; Heating;
DOI:10.1021/jo005512a

Reference yield: 91.0%

: 64-17-5
ethanol

: 304443-32-1
6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

: ethyl 6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo005512a

Reference yield: 37.0%

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 304443-32-1
6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

: 6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydropyrimidin-4-yl-(4-chlorophenyl)methanone

Guidance literature:: 6-(3,5-dimethylphenyl)-2-oxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid; With 4-methyl-morpholine; N,O-dimethylhydroxylamine*hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; In N,N-dimethyl-formamide; at 20 ℃;

(4-chlorphenyl)magnesium bromide; In tetrahydrofuran; at 20 ℃; for 5h; Further stages.;
DOI:10.1021/jo005512a