7H-Dibenzo[de,g]quinolin-7-one

Base Information

• Chemical Name: 7H-Dibenzo[de,g]quinolin-7-one
• CAS No.: 38750-39-9
• Molecular Formula: C₁₆H₉NO
• Molecular Weight: 231.254
• Mol file: 38750-39-9.mol

Synonyms:NSC 296570

Chemical Property of 7H-Dibenzo[de,g]quinolin-7-one

Chemical Property:

• Vapor Pressure: 7.71E-09mmHg at 25°C
• Boiling Point: 465.4°Cat760mmHg
• Flash Point: 238.9°C
• Density: 1.343g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7H-Dibenzo[de,g]quinolin-7-one

There total 10 articles about 7H-Dibenzo[de,g]quinolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(isoquinolin-8-yl)benzaldehyde → 7H-dibenzo[de,g]quinolin-7-one (38750-39-9)

Guidance literature:

With tert.-butylhydroperoxide; iron(II) sulfate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 90 ℃; Reagent/catalyst; Solvent; Temperature;

DOI:10.1016/j.ejmech.2022.114141

Reference yield: 83.0%

8-bromo-isoquinoline (63927-22-0) + 2-formylbenzene boronic acid (40138-16-7) → 7H-dibenzo[de,g]quinolin-7-one (38750-39-9)

Guidance literature:

8-bromo-isoquinoline; 2-formylbenzene boronic acid; With potassium carbonate; sodium sulfate; palladium dichloride; In isopropyl alcohol; at 85 ℃; for 8h;

With tert.-butylhydroperoxide; iron(II) sulfate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 90 ℃; for 10h;

DOI:10.1016/j.ejmech.2022.114141

Reference yield: 60.0%

7-oxo-7H-dibenzo[de,g]quinoline-4,5-dicarboxylic acid (1160852-12-9) → 7H-dibenzo[de,g]quinolin-7-one (38750-39-9)

Guidance literature:

In diphenylether; at 230 - 250 ℃;

DOI:10.3109/14756366.2013.845818

upstream raw materials:

1-iodoisoquiniline

(2-bromophenyl)(isoquinolin-1-yl)methanone

1-isoquinolone

(2-bromophenyl)isoquinolin-1-yl-acetonitrile

Refernces

• 1、 Chen, Yin,Chen, Zhen-Feng,Choudhary, Muhammad Iqbal,Liang, Hong,Liao, Lan-Shan,Pan, Ying-Ming,Su, Gui-Fa,Tan, Lin-Jie,Tang, Hai-Tao,Yang, Qi-Yuan. "One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions". supporting information. . Retrieved 2022/02/01.
• 2、 Chuang, Ta-Hsien,Li, Chien-Fu,Lee, Hong-Zin,Wen, Yu-Chia. "Direct conversion of 1-(2-bromobenzoyl)isoquinolines to dibenzo[ de,g ]quinolin-7-ones via reductive photocyclization". . p. 4974 - 4984. Retrieved 2013/06/27.