2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol

Base Information

• Chemical Name: 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol
• CAS No.: 1067914-75-3
• Molecular Formula: C₁₉H₁₇N₃O₃
• Molecular Weight: 335.362
• Mol file: 1067914-75-3.mol

Synonyms:2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol

Chemical Property of 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol

There total 14 articles about 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline (1067914-77-5) → 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol (1067914-75-3)

Guidance literature:

With 10% palladium hydroxide on charcoal; ammonium formate; In ethanol; for 2h; Reflux;

DOI:10.1021/ml4003953

Reference yield:

8-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-1,4-dioxa-8-azaspiro[4.5]decane (1067914-74-2) → 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol (1067914-75-3) + 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-one (1067914-73-1)

Guidance literature:

8-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-1,4-dioxa-8-azaspiro[4.5]decane; With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 20 ℃; for 216h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;

Reference yield:

C25H31N3O3Si → 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-ol (1067914-75-3)

Guidance literature:

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

8-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-1,4-dioxa-8-azaspiro[4.5]decane

8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

7-(2-methoxy-ethoxy)-imidazo[1,2-a]pyridine

quinoline-2,8-diol

Downstream raw materials:

N-benzyl-3,3-difluoro-1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-amine

benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate