8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Base Information

Chemical Name:8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline
CAS No.:1067914-77-5
Molecular Formula:C₂₆H₂₃N₃O₃
Molecular Weight:425.487
Hs Code.:

Synonyms:8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Suppliers and Price of 8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Chemical Property:

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Technology Process of 8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

There total 8 articles about 8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1067914-34-4
7-(2-methoxy-ethoxy)-imidazo[1,2-a]pyridine

: 343788-51-2
8-(benzyloxy)-2-chloroquinoline

: 1067914-77-5
8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 60h; Inert atmosphere;
DOI:10.1021/ml4003953

Reference yield:

: 15450-76-7
quinoline-2,8-diol

: 1067914-77-5
8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide; water / 19 h / 65 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 85 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate / water; 1,4-dioxane / 60 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium diacetate; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3: |Heck Reaction;
DOI:10.1021/ml4003953

Reference yield:

: 100-39-0
benzyl bromide

: 1067914-77-5
8-(benzyloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide; water / 19 h / 65 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 85 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate / water; 1,4-dioxane / 60 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium diacetate; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3: |Heck Reaction;
DOI:10.1021/ml4003953