4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

Base Information

Chemical Name:4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran
CAS No.:249766-62-9
Molecular Formula:C₁₈H₃₆O₃Si
Molecular Weight:328.568
Hs Code.:

Synonyms:4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

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Technology Process of 4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

There total 8 articles about 4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-77-4
chloro-trimethyl-silane

: 249766-59-4
4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-tetrahydrofuran-4-ol

: 249766-62-9
4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00612-2

Reference yield:

: 4361-28-8
3-cyclohexylpropanal

: 249766-62-9
4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N / 20 °C

2.1: CF₃COOH / 0 °C

3.1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.5 h / -60 °C

3.2: 64 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -60 °C

4.1: 2.26 g / diethyl ether / 1.5 h / 0 °C

5.1: aq. NH₄Cl / tetrahydrofuran / 60 - 70 °C

6.1: 41 percent / diethyl ether / 0 °C

7.1: 56 percent / p-toluenesulfonic acid monohydrate / methanol / 20 °C

8.1: 89 percent / imidazole / dimethylformamide

With 1H-imidazole; ammonium chloride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; N,N-dimethyl-formamide; 1.1: Addition / 2.1: Addition / 3.1: Metallation / 3.2: Alkylation / 4.1: Addition / 5.1: Hydrolysis / 6.1: Addition / 7.1: Cyclization / 8.1: Substitution;
DOI:10.1016/S0040-4020(99)00612-2

Reference yield:

: 104344-07-2
4-Cyclohexyl-2-hydroxy-butyronitrile

: 249766-62-9
4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-4-[(trimethylsilyl)oxy]-tetrahydrofuran

Guidance literature:: Multi-step reaction with 7 steps

1.1: CF₃COOH / 0 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.5 h / -60 °C

2.2: 64 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -60 °C

3.1: 2.26 g / diethyl ether / 1.5 h / 0 °C

4.1: aq. NH₄Cl / tetrahydrofuran / 60 - 70 °C

5.1: 41 percent / diethyl ether / 0 °C

6.1: 56 percent / p-toluenesulfonic acid monohydrate / methanol / 20 °C

7.1: 89 percent / imidazole / dimethylformamide

With 1H-imidazole; ammonium chloride; toluene-4-sulfonic acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; N,N-dimethyl-formamide; 1.1: Addition / 2.1: Metallation / 2.2: Alkylation / 3.1: Addition / 4.1: Hydrolysis / 5.1: Addition / 6.1: Cyclization / 7.1: Substitution;
DOI:10.1016/S0040-4020(99)00612-2