(E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

Base Information

Chemical Name:(E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide
CAS No.:691869-45-1
Molecular Formula:C₁₉H₂₉NO₅
Molecular Weight:351.443
Hs Code.:

Synonyms:(E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

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Chemical Property of (E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

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Technology Process of (E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

There total 3 articles about (E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-88-4
methyl iodide

: 691869-44-0
(E)-(2R,3R)-3-Hydroxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

: 691869-45-1
(E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1021/ol049701h

Reference yield:

: 197227-70-6
(2E)-4-[(4-methoxybenzyl)oxy]-2-methylbut-2-enal

: 691869-45-1
(E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dibutylboron triflate; Et₃N / CH₂Cl₂ / 0.42 h / 0 °C

1.2: 85 percent / CH₂Cl₂ / -78 - 20 °C

2.1: trimethylaluminum / tetrahydrofuran; toluene / 0.83 h / 20 °C

2.2: tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C

3.1: 3.4 g / NaH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C

With di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Evans aldol reaction / 1.2: Evans aldol reaction;
DOI:10.1021/ol049701h

Reference yield:

: 691869-33-7
(R)-4-Benzyl-3-[(E)-(2R,3R)-3-hydroxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoyl]-oxazolidin-2-one

: 691869-45-1
(E)-(2R,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / tetrahydrofuran; toluene / 0.83 h / 20 °C

1.2: tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C

2.1: 3.4 g / NaH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C

With trimethylaluminum; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol049701h