(S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Base Information

• Chemical Name: (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride
• CAS No.: 248921-72-4
• Molecular Formula: C₃₄H₄₄F₂N₂O*ClH
• Molecular Weight: 571.194
• Mol file: 248921-72-4.mol

Synonyms:(S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Chemical Property of (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

There total 4 articles about (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethereal HCl + (S)-4-Methyl-2-methylamino-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride (248921-70-2) + 4-tert-Butylbenzaldehyde (939-97-9) + sodium hydrogencarbonate (144-55-8) → (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride (248921-72-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; In diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile;

Reference yield:

N-t-butoxycarbonyl-N-methyl-L-leucine (53363-89-6) → (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride (248921-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / diethyl ether; N,N-dimethyl-formamide

2: hydrogenchloride; trifluoroacetic acid / methanol; diethyl ether; dichloromethane; chloroform

3: sodium tris(acetoxy)borohydride / diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile

With hydrogenchloride; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(S)-{1-[4,4-bis-(4-fluoro-phenyl)-butylcarbamoyl]-3-methyl-butyl}-methyl-carbamic acid tert-butyl ester (248922-88-5) → (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride (248921-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; trifluoroacetic acid / methanol; diethyl ether; dichloromethane; chloroform

2: sodium tris(acetoxy)borohydride / diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile

With hydrogenchloride; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile;

upstream raw materials:

(S)-4-Methyl-2-methylamino-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

4-tert-Butylbenzaldehyde

sodium hydrogencarbonate

N-t-butoxycarbonyl-N-methyl-L-leucine