Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

Base Information

Chemical Name:Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate
CAS No.:1026324-32-2
Molecular Formula:C₂₃H₂₁IO₄S
Molecular Weight:520.388
Hs Code.:

Synonyms:Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

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Chemical Property of Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

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Technology Process of Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

There total 6 articles about Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-98-5
thiophenol

: 158469-50-2
Methyl (Z)-3-<4-(5-iodo-2-methoxyphenoxy)phenyl>acrylate

: 1026324-32-2
Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 30h; Heating;
DOI:10.1021/jo00097a052

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 1026324-32-2
Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / K₂CO₃, CuO, pyridine / 21 h / 120 °C

2: 80 percent / H₅IO₆, I₂, aq. H₂SO₄ / acetic acid / 2 h / 90 °C

3: 99 percent / DIBAL-H / diethyl ether; cyclohexane / 7 h / -78 °C

4: 94 percent / KN(TMS)2, 18-crown-6 / tetrahydrofuran; toluene / 1.) -78 deg C, 10 min, 2.) -78 deg C, 10 h

5: 94 percent / DBU / tetrahydrofuran / 30 h / Heating

With pyridine; 18-crown-6 ether; sulfuric acid; iodine; potassium hexamethylsilazane; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; periodic acid; copper(II) oxide; In tetrahydrofuran; diethyl ether; cyclohexane; acetic acid; toluene;
DOI:10.1021/jo00097a052

Reference yield:

: 78338-67-7
4-(2'-methoxyphenoxy)benzonitrile

: 1026324-32-2
Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / H₅IO₆, I₂, aq. H₂SO₄ / acetic acid / 2 h / 90 °C

2: 99 percent / DIBAL-H / diethyl ether; cyclohexane / 7 h / -78 °C

3: 94 percent / KN(TMS)2, 18-crown-6 / tetrahydrofuran; toluene / 1.) -78 deg C, 10 min, 2.) -78 deg C, 10 h

4: 94 percent / DBU / tetrahydrofuran / 30 h / Heating

With 18-crown-6 ether; sulfuric acid; iodine; potassium hexamethylsilazane; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; periodic acid; In tetrahydrofuran; diethyl ether; cyclohexane; acetic acid; toluene;
DOI:10.1021/jo00097a052