78338-67-7Relevant articles and documents
2,4-Diaminotriazines as anti-infective agents
De, Suparna S.,Vogalu, Siva K.,Ansari, Nazima,Patil, Rajendra,Sriram, Dharmarajan,Degani, Mariam S.
, p. 1211 - 1215 (2020/12/04)
Triazines are scaffolds of interest to medicinal chemists as they have a wide variety of pharmacological activities. Molecules with the triazine moiety have been explored extensively for their anti-infective potential. In this paper, we report a series of
Synthesis of diaryl ethers, diaryl sulfides, heteroaryl ethers and heteroaryl sulfides under microwave dielectric heating
Li, Feng,Meng, Qingqing,Chen, Huansheng,Li, Zhiming,Wang, Quanrui,Tao, Fenggang
, p. 1305 - 1313 (2007/10/03)
This paper describes the synthesis of diaryl ethers and sulfides by utilizing microwave heating methodology. The methodology is shown to be rapid and efficient for the coupling of phenols or thiophenol with electron-deficient aryl halides through a SNAr reaction. The scope of the protocol can be expanded to six-membered heterocycles bearing a hydroxyl group as well as to the reaction of 2-pyrimidinethiol with mildly activated aryl halides, providing heteroaryl ethers and sulfides, respectively. The advantages of the present method include the wide substrate scope, the obviation of metal catalysts, ease of product isolation, and high purity of products. Georg Thieme Verlag Stuttgart.
Microwave-assisted synthesis of diaryl ethers without catalyst
Li, Feng,Wang, Quanrui,Ding, Zongbiao,Tao, Fenggang
, p. 2169 - 2171 (2007/10/03)
(Matrix presented) Diaryl ethers have been prepared by direct coupling of phenols including those that bear a strong electron-attracting substituent to electron-deficient aryl halides through SNAr-based addition reactions with assistance of microwave irradiation in high to excellent yields within 5-10 min. No catalysts were required under our conditions.
