(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

Base Information

Chemical Name:(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester
CAS No.:213533-00-7
Molecular Formula:C₃₁H₄₀O₇SSi
Molecular Weight:584.806
Hs Code.:

Synonyms:(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

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Chemical Property of (R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

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Technology Process of (R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

There total 4 articles about (R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124-63-0
methanesulfonyl chloride

: 187851-97-4
(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

: 213533-00-7
(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1055/s-1998-2123

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 213533-00-7
(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 95 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-2123

Reference yield:

: 187851-95-2
(4-methoxyphenyl)methyl hex-5-enoate

: 213533-00-7
(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-bis(dihydroquininyl)anthraquinone, K₃Fe(CN)6, K₂CO₃, NaHCO₃, potassium osmate(VI) dihydrate, H₂O / 2-methyl-propan-2-ol / 12 h / 0 °C

2: 91 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 95 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With 1H-imidazole; potassium osmate(VI); 1,4-bis(dihydroquinidinyl)anthraquinone; water; sodium hydrogencarbonate; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1055/s-1998-2123