(4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

Base Information

Chemical Name:(4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone
CAS No.:911297-36-4
Molecular Formula:C₁₈H₂₁NO₂Si
Molecular Weight:311.456
Hs Code.:

Synonyms:(4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

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Chemical Property of (4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

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Technology Process of (4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

There total 8 articles about (4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 911297-40-0
2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenylboronic acid

: 62348-24-7
4-Methyl-5-oxazolecarbonyl chloride

: 911297-36-4
(4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In toluene; at 60 ℃; for 2h;
DOI:10.1021/ol061697h

Reference yield:

: 911297-37-5
2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenol

: 911297-36-4
(4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 24.88 g / N,N-dimethylaminopyridine; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: 86 percent / Pd(OAc)2; bis[2-(diphenylphosphino)phenyl] ether; Et₃N / dioxane / 19 h / 60 °C

3: NaIO₄; AcOH / tetrahydrofuran / 65 h / 45 °C

4: 78 percent / PdCl₂(PPh₃)2; K₃PO₄*H₂O / toluene / 2 h / 60 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; potassium phosphate; sodium periodate; acetic acid; triethylamine; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; 4: Suzuki reaction;
DOI:10.1021/ol061697h

Reference yield:

: 911297-39-7
4,4,5,5-tetramethyl-2-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]-[1,3,2]dioxaborolane

: 911297-36-4
(4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: NaIO₄; AcOH / tetrahydrofuran / 65 h / 45 °C

2: 78 percent / PdCl₂(PPh₃)2; K₃PO₄*H₂O / toluene / 2 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; sodium periodate; acetic acid; In tetrahydrofuran; toluene; 2: Suzuki reaction;
DOI:10.1021/ol061697h