2-Amino-N-(2-hydroxyethyl)benzamide

Base Information

• Chemical Name: 2-Amino-N-(2-hydroxyethyl)benzamide
• CAS No.: 49667-81-4
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.206
• Hs Code.: 2924299090
• European Community (EC) Number: 256-421-7
• DSSTox Substance ID: DTXSID50197959
• Nikkaji Number: J319.999A
• Wikidata: Q83070715
• Mol file: 49667-81-4.mol

Synonyms:2-Amino-N-(2-hydroxyethyl)benzamide;49667-81-4;EINECS 256-421-7;SCHEMBL1204120;DTXSID50197959;TWRJRCKCJRVPKH-UHFFFAOYSA-N;BBL023432;MFCD00456226;STL356020;AKOS009375054;N1-(2-Hydroxyethyl)-2-aminobenzamide;SB85167;VS-07428;EN300-84316;Z390185000

Chemical Property of 2-Amino-N-(2-hydroxyethyl)benzamide

Chemical Property:

• Vapor Pressure: 2.14E-08mmHg at 25°C
• Boiling Point: 436.6°Cat760mmHg
• PKA: 13.70±0.46(Predicted)
• Flash Point: 217.9°C
• PSA: 78.84000
• Density: 1.233g/cm³
• LogP: 1.14690
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 173

Purity/Quality:

99% ^*data from raw suppliers

2-amino-N-(2-hydroxyethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NCCO)N

Technology Process of 2-Amino-N-(2-hydroxyethyl)benzamide

There total 4 articles about 2-Amino-N-(2-hydroxyethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

isatoic anhydride (118-48-9) + ethanolamine (141-43-5) → 2-amino-N-(2-hydroxyethyl)benzamide (49667-81-4)

Guidance literature:

In 1,4-dioxane; at 20 - 40 ℃; for 4h;

Reference yield: 81.0%

anthranil (271-58-9) + ethanolamine (141-43-5) → 2-amino-N-(2-hydroxyethyl)benzamide (49667-81-4)

Guidance literature:

With toluene-4-sulfonic acid; at 140 ℃; for 3h;

DOI:10.1002/ejoc.202100756

Reference yield: 60.0%

isatoic anhydride (118-48-9) + ethanolamine (141-43-5) → 2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline (3416-93-1) + 2-amino-N-(2-hydroxyethyl)benzamide (49667-81-4)

Guidance literature:

With sodium acetate; In acetic acid; for 4h; Heating;

DOI:10.1081/SCC-100106216

upstream raw materials:

isatoic anhydride

ethanolamine

anthranil

Downstream raw materials:

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline

3-(2-hydroxyethyl)-2-(4-methoxyphenyl)-4(3H)-quinazolinone

3-(2-hydroxyethyl)-2-phenyl-quinazoline-(3H)-4-one

2-(4-chloro-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)-N-(2-hydroxyethyl)benzamide