trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

Base Information

Chemical Name:trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride
CAS No.:691880-06-5
Molecular Formula:C₂₄H₂₈N₂O*ClH
Molecular Weight:396.96
Hs Code.:

Synonyms:trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

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Chemical Property of trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

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Technology Process of trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

There total 7 articles about trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 691880-06-5
trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane

2: chloro-trimethyl-silane / butanone / 3 h / 20 °C

With chloro-trimethyl-silane; In dichloromethane; butanone; 1: |Pictet-Spengler Synthesis;
DOI:10.1021/ml500116x

Reference yield:

: trans-4-(dimethylamino)-4-phenyl-4',9'-dihydro-3’H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]

: 691880-06-5
trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

Guidance literature:: With chloro-trimethyl-silane; In butanone; at 20 ℃; for 3h;
DOI:10.1021/ml500116x DOI:10.1021/ml500117c

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 691880-06-5
trans-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; water

2.1: tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / water

4.1: dichloromethane

5.1: chloro-trimethyl-silane / butanone / 3 h / 20 °C

With hydrogenchloride; chloro-trimethyl-silane; In tetrahydrofuran; methanol; dichloromethane; water; butanone; 1.1: |Strecker Aminoacid Synthesis / 2.1: |Bruylants Amination / 4.1: |Pictet-Spengler Synthesis;
DOI:10.1021/ml500116x