phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

Base Information

Chemical Name:phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate
CAS No.:1253799-49-3
Molecular Formula:C₂₂H₁₈BrFO₄
Molecular Weight:445.285
Hs Code.:

Synonyms:phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

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Chemical Property of phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

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Technology Process of phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

There total 8 articles about phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1253799-47-1
phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-formyl-6-methylbenzoate

: 1253799-49-3
phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; for 0.5h;

Reference yield:

: 394-04-7
5-fluoro-2-methoxybenzoic acid

: 1253799-49-3
phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 2 h / -78 °C

1.2: 2 h / -78 - 25 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 25 °C

2.2: 12 h / 25 °C

3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

4.1: bromine; acetic acid / 2 h / 20 °C

5.1: potassium carbonate / acetone / 3 h / 0 - 50 °C

6.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

6.2: 1 h / -78 - -20 °C

7.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; bromine; sec.-butyllithium; boron tribromide; potassium carbonate; acetic acid; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1207283-54-2
phenyl 3-fluoro-6-methoxy-2-methylbenzoate

: 1253799-49-3
phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-(hydroxymethyl)-6-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

2.1: bromine; acetic acid / 2 h / 20 °C

3.1: potassium carbonate / acetone / 3 h / 0 - 50 °C

4.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

4.2: 1 h / -78 - -20 °C

5.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; bromine; boron tribromide; potassium carbonate; acetic acid; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone;