((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester
• CAS No.: 186261-93-8
• Molecular Formula: C₁₇H₂₄N₂O₅S
• Molecular Weight: 368.454
• Mol file: 186261-93-8.mol

Synonyms:((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester

Chemical Property of ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester

There total 4 articles about ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminocaprolactam (21568-87-6) → ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester (186261-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

2: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

3: 100 percent / HCl / ethyl acetate / 0 - 20 °C

4: Et₃N / acetonitrile / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; acetonitrile;

DOI:10.1021/jm960572n

Reference yield:

(S)-3-amino-hexahydro-2-oxo-1H-azepine-1-acetic acid, ethyl ester, hydrochloride salt + benzenesulfonyl chloride (1939-99-7) → ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester (186261-93-8)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃;

DOI:10.1021/jm960572n

Reference yield:

tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate (76944-95-1) → ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid ethyl ester (186261-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

2: 100 percent / HCl / ethyl acetate / 0 - 20 °C

3: Et₃N / acetonitrile / 0 - 20 °C

With hydrogenchloride; triethylamine; lithium hexamethyldisilazane; In ethyl acetate; acetonitrile;

DOI:10.1021/jm960572n

upstream raw materials:

benzenesulfonyl chloride

tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

2-aminocaprolactam

Downstream raw materials:

C₂₃H₃₅N₇O₇S

N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

(3S)-hexahydro-2-oxo-3-[[(phenylmethyl)sulfonyl]amino]-1H-azepine-1-acetic acid