Technology Process of 4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate
There total 1 articles about 4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice
2.1: n-butyllithium / tetrahydrofuran / 3 h / -20 °C
2.2: -20 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
4.1: sodium hydride / tetrahydrofuran / Inert atmosphere; Cooling with ice
4.2: Reflux
5.1: hydrogen / Raney nickel / tetrahydrofuran
6.1: hydrogenchloride / 1,4-dioxane / 3 h / Reflux
6.2: 20 °C / pH 8
7.1: hydrogen / palladium 10% on activated carbon / ethanol
8.1: triethylamine / dichloromethane / 6 h / 20 °C
With
hydrogenchloride; n-butyllithium; hydrogen; sodium hydride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
With
triethylamine; sodium iodide;
In
acetonitrile;
at 70 ℃;
- Guidance literature:
-
4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate;
With
sodium iodide;
In
acetonitrile;
for 0.5h;
Reflux;
1-(2-methoxyphenyl)piperazine hydrochloride;
With
potassium carbonate;
In
acetonitrile;
for 4h;
Reflux;
