3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

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Chemical Name:3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester
CAS No.:157035-17-1
Molecular Formula:C₃₄H₄₆O₆Si
Molecular Weight:578.821
Hs Code.:

Synonyms:3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

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Chemical Property of 3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

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Technology Process of 3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

There total 9 articles about 3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 84428-16-0
ethyl 3-(3'-hydroxy-4'-methoxyphenyl)propanoate

: 157035-16-0
[1-Benzyloxymethyl-2-(4-bromo-phenyl)-ethoxy]-tert-butyl-dimethyl-silane

: 157035-17-1
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

Guidance literature:: With copper(I) bromide dimethylsulfide complex; potassium carbonate; In pyridine; at 140 ℃; for 6h;
DOI:10.1016/S0040-4039(00)73369-7

Reference yield:

: 24393-53-1,136265-11-7,15795-20-7
ethyl (E)-3-(4-bromophenyl)-2-propenoate

: 157035-17-1
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / DIBAL-H / CH₂Cl₂; hexane / 0.17 h / -78 °C

2: 94 percent / NaH, Bu₄NI / tetrahydrofuran / 1.) 0 to 25 deg C, 30 min, 2.) 25 deg C, 3 h

3: 82 percent / m-CPBA / CH₂Cl₂ / 4 h / 25 °C

4: 86 percent / DIBAL-H / toluene / 0.17 h / 0 °C

5: 97 percent / imidazole / dimethylformamide / 3 h / 25 °C

6: 92 percent / K₂CO₃, CuBr*Me₂S / pyridine / 6 h / 140 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8

Reference yield:

: 157035-15-9
O-benzyl-3-(4-bromophenyl)-2-hydroxypropanol

: 157035-17-1
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 3 h / 25 °C

2: 92 percent / K₂CO₃, CuBr*Me₂S / pyridine / 6 h / 140 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; potassium carbonate; In pyridine; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8