N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

Base Information

Chemical Name:N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride
CAS No.:1187668-67-2
Molecular Formula:C₁₈H₂₀N₄S*ClH
Molecular Weight:360.911
Hs Code.:

Synonyms:N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

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Chemical Property of N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

Chemical Property:

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Technology Process of N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

There total 8 articles about N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1187668-63-8
2-(4-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl)ethanol

: 124-63-0
methanesulfonyl chloride

: 124-40-3
dimethyl amine

: 1187668-67-2
N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

Guidance literature:: 2-(4-{[4-(4-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl)ethanol; methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

dimethyl amine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16.0833h;
DOI:10.1021/jm901457w

Reference yield:

: 1187668-66-1
N-{4-[2-dimethylamino-ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine

: 1187668-67-2
N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate; Purification / work up;

Reference yield:

: 1-(4-(2-hydroxyethyl)phenyl)thiourea

: 1187668-67-2
N-{4-[2-(dimethylamino)ethyl]phenyl}-4-(4-pyridinyl)-1,3-thiazol-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 4 h / Heating; Reflux

1.2: 1 h / 0 - 20 °C / pH ~ 8

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / methanol; ethyl acetate

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Hantzsch thiazole synthesis;