(R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

Base Information

Chemical Name:(R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate
CAS No.:1061742-95-7
Molecular Formula:C₃₁H₃₈N₂O₆S
Molecular Weight:566.719
Hs Code.:

Synonyms:(R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

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Technology Process of (R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

There total 5 articles about (R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: (R)-4-tert-butoxy-3-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-oxobutan-1-aminium acetate

: 103-80-0
phenylacetyl chloride

: 1061742-95-7
(R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1021/acs.jmedchem.5b00367

Reference yield: 16.0%

: 1061742-95-7
(R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

Guidance literature:

Reference yield:

: 849773-54-2
tert-butyl (2S)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate

: 1061742-95-7
(R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 17 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.5b00367