{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester
CAS No.:1350445-25-8
Molecular Formula:C₂₆H₃₆FNO₃Si
Molecular Weight:457.661
Hs Code.:

Synonyms:{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

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Chemical Property of {4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of {4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

There total 4 articles about {4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1350445-26-9
4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

: 501-53-1,94274-21-2
benzyl chloroformate

: 1350445-25-8
{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 865869-24-5
trifluoro-methanesulfonic acid 4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl ester

: 1350445-25-8
{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.67 h / 100 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 4 h / 20 °C / Inert atmosphere

3: potassium carbonate / dichloromethane / 0 - 20 °C

With hydrogen; sodium carbonate; potassium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 55145-45-4
4-(tert-butyldimethylsilyloxy)cyclohexanone

: 1350445-25-8
{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.67 h / 100 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 4 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / dichloromethane / 0 - 20 °C

With hydrogen; sodium carbonate; potassium carbonate; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;