4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

Base Information

Chemical Name:4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine
CAS No.:1350445-26-9
Molecular Formula:C₁₈H₃₀FNOSi
Molecular Weight:323.526
Hs Code.:

Synonyms:4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

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Chemical Property of 4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

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Technology Process of 4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

There total 3 articles about 4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1350445-22-5
{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl]-2-fluoro-phenyl}-carbamic acidbenzyl ester

: 1350445-26-9
4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 865869-24-5
trifluoro-methanesulfonic acid 4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl ester

: 1350445-26-9
4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.67 h / 100 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 4 h / 20 °C / Inert atmosphere

With hydrogen; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 55145-45-4
4-(tert-butyldimethylsilyloxy)cyclohexanone

: 1350445-26-9
4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.67 h / 100 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 4 h / 20 °C / Inert atmosphere

With hydrogen; sodium carbonate; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;