(R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

Base Information

Chemical Name:(R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine
CAS No.:144301-82-6
Molecular Formula:C₁₇H₂₂Cl₂N₂O
Molecular Weight:341.28
Hs Code.:

Synonyms:(R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

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Chemical Property of (R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

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Technology Process of (R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

There total 4 articles about (R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 60419-23-0
(R)-(-)-1-(2-pyrrolidinylmethyl)pyrrolidine

: 144301-82-6
(R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00101a011

Reference yield:

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 144301-82-6
(R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole (HOBT) / CH₂Cl₂ / Ambient temperature

2: 100 percent / TFA / CH₂Cl₂ / 0.83 h / Ambient temperature

3: 91 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

4: 35 percent / DCC / CH₂Cl₂ / 0.17 h / Ambient temperature

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00101a011

Reference yield:

: 144243-45-8,202990-49-6
(R)-(+)-1-prolinamidopyrrolidine

: 144301-82-6
(R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

2: 35 percent / DCC / CH₂Cl₂ / 0.17 h / Ambient temperature

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00101a011