(S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

Base Information

Chemical Name:(S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one
CAS No.:1092807-24-3
Molecular Formula:C₂₁H₁₃F₁₂NO₂
Molecular Weight:539.321
Hs Code.:

Synonyms:(S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

Suppliers and Price of (S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of (S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

There total 2 articles about (S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 112981-69-8
3,5-bis(trifluoromethyl)phenylmagnesium bromide

: 4931-66-2
methyl (S)-pyroglutamate

: 1092807-24-3
(S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

Guidance literature:: In tetrahydrofuran; Inert atmosphere;
DOI:10.1055/s-2008-1067216

Reference yield:

: 535949-95-2
(3,5-bis(trifluoromethyl)phenyl)magnesium chloride

: 98-79-3
L-Pyroglutamic acid

: 1092807-24-3
(S)-5-{bis[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}pyrrolidin-2-one

Guidance literature:: L-Pyroglutamic acid; With methanol;

(3,5-bis(trifluoromethyl)phenyl)magnesium chloride; In tetrahydrofuran;
DOI:10.1021/acs.orglett.9b03509