1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

Base Information

Chemical Name:1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane
CAS No.:1220122-71-3
Molecular Formula:C₁₇H₂₂FN₃O₃S
Molecular Weight:367.444
Hs Code.:

Synonyms:1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

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Chemical Property of 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

There total 1 articles about 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676-58-4
methylmagnesium chloride

: 147118-37-4
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

: 1220122-72-4
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

: 1220122-71-3
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

Guidance literature:: methylmagnesium chloride; N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water; at 0 - 10 ℃;

Reference yield:

: 1220122-72-4
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

: 1220122-71-3
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 890028-66-7
(E)-N-[4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl]-N-methyl methanesulfoneamide

Guidance literature:: 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene; 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane; N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 85 ℃; for 36h;

With sodium hydroxide; In water; for 1h; pH=8 - 8.5; Product distribution / selectivity; Cooling with ice;