1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

Base Information

Chemical Name:1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene
CAS No.:1220122-72-4
Molecular Formula:C₁₇H₂₀FN₃O₂S
Molecular Weight:349.429
Hs Code.:

Synonyms:1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

Suppliers and Price of 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

There total 2 articles about 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methanesulfonyl)amino]]-5-pyrimidinyl]methylphenyltriphenylphosphonium bromide

: 1220122-72-4
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

: 676-58-4
methylmagnesium chloride

: 147118-37-4
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

: 1220122-72-4
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

: 1220122-71-3
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

Guidance literature:: methylmagnesium chloride; N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water; at 0 - 10 ℃;

Reference yield:

: 1220122-72-4
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene

: 1220122-71-3
1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 890028-66-7
(E)-N-[4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl]-N-methyl methanesulfoneamide

Guidance literature:: 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-ethene; 1-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]-pyrimidin-5-yl]-1-hydroxyethane; N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 85 ℃; for 36h;

With sodium hydroxide; In water; for 1h; pH=8 - 8.5; Product distribution / selectivity; Cooling with ice;