N-phenylacetylphenylalanine methyl ester

Base Information

• Chemical Name: N-phenylacetylphenylalanine methyl ester
• CAS No.: 159754-01-5
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.354
• Mol file: 159754-01-5.mol

Synonyms:N-phenylacetylphenylalanine methyl ester

Chemical Property of N-phenylacetylphenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylacetylphenylalanine methyl ester

There total 5 articles about N-phenylacetylphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) → N-phenylacetylphenylalanine methyl ester (159754-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 60 °C

2: triethylamine / dichloromethane / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1016/j.crci.2011.08.005

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) → N-phenylacetylphenylalanine methyl ester (159754-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0 °C / Reflux

2: triethylamine / dichloromethane / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/j.crci.2011.08.005

Reference yield:

methyl 2-amino-3-phenylpropanoate hydrochloride (5619-07-8) + phenylacetyl chloride (103-80-0) → N-phenylacetylphenylalanine methyl ester (159754-01-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.crci.2011.08.005

upstream raw materials:

phenylacetyl chloride

phenylacetic acid

Phenylalanine

methyl 2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

methanol