4-Chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate

Base Information

• Chemical Name: 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate
• CAS No.: 1184936-21-7
• Molecular Formula: C₈H₅ClF₃NO*ClH*H₂O
• Molecular Weight: 278.058
• Mol file: 1184936-21-7.mol

Synonyms:4-Chloro-2-trifluoroacetyl-aniline, hydrochloride hydrate

Chemical Property of 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate

Chemical Property:

Purity/Quality:

≥99.0% ^*data from raw suppliers

1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanonehydrochloridehydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate

There total 1 articles about 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl trifluoroacetate, (383-63-1) + N-(4-chlorophenyl)-2,2-dimethylpropionamide (65854-91-3) → 4-Chloro-2-trifluoroacetyl-aniline, hydrochloride hydrate (1184936-21-7)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; acetic acid; In hydrogenchloride; hexane; tert-butyl methyl ether;

Reference yield:

4-Chloro-2-trifluoroacetyl-aniline, hydrochloride hydrate (1184936-21-7) + 4-Methoxybenzyl alcohol (105-13-5) → 1-{5-chloro-2-[(4-methoxybenzyl)amino]phenyl}-2,2,2-trifluoroethan-1-one (173676-54-5)

Guidance literature:

With sodium hydroxide; TSOH; In tetrahydrofuran; n-heptane; water; toluene;

Reference yield:

diisopropylethyl amine (861359-74-2) + triphenylmethyl alcohol (76-84-6) + 4-Chloro-2-trifluoroacetyl-aniline, hydrochloride hydrate (1184936-21-7) → 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one (209460-09-3)

Guidance literature:

With TSOH; In cyclohexane; water; acetonitrile;

upstream raw materials:

ethyl trifluoroacetate,

N-(4-chlorophenyl)-2,2-dimethylpropionamide

Downstream raw materials:

1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one

1-{5-chloro-2-[(4-methoxybenzyl)amino]phenyl}-2,2,2-trifluoroethan-1-one

Refernces

• 1、 -. "Synthesis of cyclopropylacetylene". . . Retrieved 2008/06/13.
• 2、 -. "Asymmetric synthesis of benzoxazinones". . . Retrieved 2008/06/13.