ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

Base Information

Chemical Name:ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride
CAS No.:863578-93-2
Molecular Formula:C₁₆H₂₀N₂O₃*ClH
Molecular Weight:324.807
Hs Code.:

Synonyms:ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

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Chemical Property of ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

Chemical Property:

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Technology Process of ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

There total 5 articles about ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 863578-92-1
ethyl (2E)-3-{4-[(1-[(tert-butoxycarbonyl)amino]cyclobutylcarbonyl)amino]phenyl}prop-2-enoate

: 863578-93-2
ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h;

Reference yield:

: 120728-10-1
1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid

: 863578-93-2
ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: triethylamine / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 15 h / 85 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 863578-93-2
ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: triethylamine / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 15 h / 85 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide;