3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester

Base Information

• Chemical Name: 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester
• CAS No.: 129780-03-6
• Molecular Formula: C₁₆H₂₄INO₂
• Molecular Weight: 389.277
• Mol file: 129780-03-6.mol

Synonyms:3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester

Chemical Property of 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester

There total 4 articles about 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(diethylamino)ethyl 2-methyl-2-phenyl-3-chloropropanoate (129780-01-4) → 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester (129780-03-6)

Guidance literature:

With perhydrodibenzo-18-crown-6; potassium iodide; In acetonitrile; for 288h; Heating;

DOI:10.1021/jm00385a028

Reference yield:

3-hydroxy-2-methyl-2-phenylpropanoic acid (4370-81-4) → 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester (129780-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / thionyl chloride / 3 h / Heating

2: 80 percent / benzene / 20 h / Heating

3: 99 percent / dicyclohexyl-18-crown-6, potassium iodide / acetonitrile / 288 h / Heating

With perhydrodibenzo-18-crown-6; thionyl chloride; potassium iodide; In acetonitrile; benzene;

DOI:10.1021/jm00385a028

Reference yield:

ethyl 3-hydroxy-2-methyl-2-phenylpropanoate (16141-26-7) → 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester (129780-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 76.8 percent / 10percent aq. NaOH / a) RT, 3 h, b) 60 deg C, 1.5 h

2: 58 percent / thionyl chloride / 3 h / Heating

3: 80 percent / benzene / 20 h / Heating

4: 99 percent / dicyclohexyl-18-crown-6, potassium iodide / acetonitrile / 288 h / Heating

With perhydrodibenzo-18-crown-6; sodium hydroxide; thionyl chloride; potassium iodide; In acetonitrile; benzene;

DOI:10.1021/jm00385a028

upstream raw materials:

2-(diethylamino)ethyl 2-methyl-2-phenyl-3-chloropropanoate

3-hydroxy-2-methyl-2-phenylpropanoic acid

ethyl 3-hydroxy-2-methyl-2-phenylpropanoate

2-phenyl-2-(chloromethyl)propanoyl chloride