N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

Base Information

Chemical Name:N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine
CAS No.:1033585-44-2
Molecular Formula:C₂₄H₁₉ClF₃N₃O₂S
Molecular Weight:505.948
Hs Code.:

Synonyms:N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

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Chemical Property of N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

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Technology Process of N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

There total 8 articles about N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1033586-42-3
4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

: 373384-18-0
3-(methanesulfonyl)phenylboronic acid

: 1033585-44-2
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

Guidance literature:: With water; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 140 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 437711-24-5
1-(2-Chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-1H-pyrazole

: 1033585-44-2
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C

2.1: hydrogenchloride / dichloromethane; water

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

5.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

6.1: tetrahydrofuran; hexane / 0.17 h / 0 °C

6.2: 1.67 h / 0 °C

7.1: water; potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; water; diisobutylaluminium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water; acetonitrile; 7.1: Suzuki Coupling;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033585-44-2
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

3.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran; hexane / 0.17 h / 0 °C

4.2: 1.67 h / 0 °C

5.1: water; potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With dmap; water; diisobutylaluminium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; 5.1: Suzuki Coupling;