Technology Process of 4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline
There total 7 articles about 4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-bromo-aniline;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.166667h;
5-bromomethyl-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 1.66667h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C
2.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C
3.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C
4.1: tetrahydrofuran; hexane / 0.17 h / 0 °C
4.2: 1.67 h / 0 °C
With
dmap; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane;
In
tetrahydrofuran; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C
2.1: hydrogenchloride / dichloromethane; water
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C
4.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C
5.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C
6.1: tetrahydrofuran; hexane / 0.17 h / 0 °C
6.2: 1.67 h / 0 °C
With
hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;