4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

Base Information

Chemical Name:4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline
CAS No.:1033586-42-3
Molecular Formula:C₁₇H₁₂BrClF₃N₃
Molecular Weight:430.655
Hs Code.:

Synonyms:4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

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Chemical Property of 4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

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Technology Process of 4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

There total 7 articles about 4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1033586-28-5
5-bromomethyl-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

: 106-40-1
4-bromo-aniline

: 1033586-42-3
4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

Guidance literature:: 4-bromo-aniline; In tetrahydrofuran; hexane; at 0 ℃; for 0.166667h;

5-bromomethyl-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole; In tetrahydrofuran; hexane; at 0 ℃; for 1.66667h;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033586-42-3
4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

3.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran; hexane / 0.17 h / 0 °C

4.2: 1.67 h / 0 °C

With dmap; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 437711-24-5
1-(2-Chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-1H-pyrazole

: 1033586-42-3
4-bromo-N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C

2.1: hydrogenchloride / dichloromethane; water

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

5.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

6.1: tetrahydrofuran; hexane / 0.17 h / 0 °C

6.2: 1.67 h / 0 °C

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;