N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

Base Information

Chemical Name:N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine
CAS No.:1033575-67-5
Molecular Formula:C₂₅H₂₁ClF₃N₃O₂S
Molecular Weight:519.975
Hs Code.:

Synonyms:N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

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Chemical Property of N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

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Technology Process of N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

There total 9 articles about N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1033585-44-2
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3'-(methylsulfonyl)biphenyl-4-amine

: 1033575-67-5
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; water; at 20 ℃; for 0.5h;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033575-67-5
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

3.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran; hexane / 0.17 h / 0 °C

4.2: 1.67 h / 0 °C

5.1: water; potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

6.1: sodium cyanoborohydride; acetic acid / methanol; water / 0.5 h / 20 °C

With dmap; water; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; water; 5.1: Suzuki Coupling;

Reference yield:

: 437711-24-5
1-(2-Chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-1H-pyrazole

: 1033575-67-5
N-((1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-N-methyl-3'-(methylsulfonyl)biphenyl-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C

2.1: hydrogenchloride / dichloromethane; water

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

5.1: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

6.1: tetrahydrofuran; hexane / 0.17 h / 0 °C

6.2: 1.67 h / 0 °C

7.1: water; potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

8.1: sodium cyanoborohydride; acetic acid / methanol; water / 0.5 h / 20 °C

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; water; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; water; acetonitrile; 7.1: Suzuki Coupling;