methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

Base Information

Chemical Name:methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate
CAS No.:1299295-04-7
Molecular Formula:C₁₈H₁₈F₃NO₃
Molecular Weight:353.341
Hs Code.:

Synonyms:methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

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Chemical Property of methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

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Technology Process of methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

There total 4 articles about methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 859828-49-2
methyl 2-{3-(trifluoromethanesulfonyloxy)phenyl}propanoate

: 349-55-3
5-(trifluoromethyl)-m-anisidine

: 1299295-04-7
methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1299295-04-7
methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 0.5 h / -20 °C

1.2: Cooling with ice

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 150 °C / Microwave irradiation

With potassium phosphate; triethylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 621-37-4
m-hydroxyphenylacetic acid

: 1299295-04-7
methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 4 h / Reflux

2.1: triethylamine / methanol / 0.5 h / -20 °C

2.2: Cooling with ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 150 °C / Microwave irradiation

With potassium phosphate; sulfuric acid; triethylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; toluene;