methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate

Base Information

• Chemical Name: methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate
• CAS No.: 147283-87-2
• Molecular Formula: C₁₀H₉F₃O₅S
• Molecular Weight: 298.24

Synonyms:methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate

Chemical Property of methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate

Chemical Property:

• Boiling Point: 330.1±42.0 °C(Predicted)
• Density: 1.464±0.06 g/cm3(Predicted)

Purity/Quality:

Methyl3-((Trifluoromethylsulfonyl)oxy)phenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl 3-((Trifluoromethylsulfonyl)oxy)phenylacetate is an intermediate in the synthesis of m-Isobutyl Ibuprofen (I780080). m-Isobutyl Ibuprofen (Ibuprofen EP Impurity A) is an Ibuprofen (I140000) impurity used in the study of potent noncompetitive interleukin-8 inhibitors.

Technology Process of methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate

There total 5 articles about methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 3-hydroxy-benzeneacetic acid, methyl ester (42058-59-3) → methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate (147283-87-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm970498o

Reference yield: 82.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-hydroxy-benzeneacetic acid, methyl ester (42058-59-3) → methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate (147283-87-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm0301078

Reference yield:

m-hydroxyphenylacetic acid (621-37-4) → methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate (147283-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂SO₄ / 8 h / Heating

2: NEt₃ / CH₂Cl₂ / 1 h / 0 °C

With sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2006.08.052

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

3-hydroxy-benzeneacetic acid, methyl ester

trifluoromethylsulfonic anhydride

m-hydroxyphenylacetic acid

Downstream raw materials:

methyl 2-{3-(trifluoromethanesulfonyloxy)phenyl}propanoate

methyl 3-(trifluoromethanesulfonyloxy)phenyldiazoacetate

(3-cyano-phenyl)-acetic acid methyl ester

methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate

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