N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

Base Information

Chemical Name:N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide
CAS No.:1364928-86-8
Molecular Formula:C₂₃H₂₀Cl₃F₃N₂O₂
Molecular Weight:519.778
Hs Code.:

Synonyms:N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

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Chemical Property of N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

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Technology Process of N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

There total 4 articles about N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364929-00-9
tert-butyl {5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

: 123-62-6
propionic acid anhydride

: 1364928-86-8
N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

Guidance literature:: tert-butyl {5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

propionic acid anhydride; With pyridine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 158401-00-4
1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone

: 1364928-86-8
N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydride / tetrahydrofuran / 8 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 20 °C

3.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 1 h / Inert atmosphere; Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.2: 3 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1338926-80-9
tert-butyl N-(5-acetylindan-1-yl)carbamate

: 1364928-86-8
N-{5-[1-oxide-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}propaneamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydride / tetrahydrofuran / 8 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 20 °C

3.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 1 h / Inert atmosphere; Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.2: 3 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;