1-(1-Adamantyl)propan-1-amine

Base Information

• Chemical Name: 1-(1-Adamantyl)propan-1-amine
• CAS No.: 60196-90-9
• Molecular Formula: C13H23 N
• Molecular Weight: 193.332
• Hs Code.: 2921300090
• DSSTox Substance ID: DTXSID70975615
• Nikkaji Number: J492.446K
• Wikipedia: Adapromine
• Wikidata: Q15634070
• Mol file: 60196-90-9.mol

Synonyms:adapromine;adapromine hydrochloride

Chemical Property of 1-(1-Adamantyl)propan-1-amine

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Boiling Point: 262.3°C at 760 mmHg
• Flash Point: 108.3°C
• PSA: 26.02000
• LogP: 3.64040
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 193.183049738
• Heavy Atom Count: 14
• Complexity: 192

Purity/Quality:

95% ^*data from raw suppliers

1-(1-Adamantyl)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C12CC3CC(C1)CC(C3)C2)N

Technology Process of 1-(1-Adamantyl)propan-1-amine

There total 4 articles about 1-(1-Adamantyl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C13H21NO2 → 1-(1-adamantyl)propan-1-amine (60196-90-9)

Guidance literature:

With hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 24h; under 38787.1 Torr;

DOI:10.1021/jacs.7b04312

Reference yield: 70.0%

1-adamantanecarbonitrile (23074-42-2) + ethyl iodide (75-03-6) → 1-(1-adamantyl)propan-1-amine (60196-90-9)

Guidance literature:

ethyl iodide; With magnesium; In diethyl ether;

1-adamantanecarbonitrile; In tetrahydrofuran; for 3h;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 25h; Further stages.; Heating;

DOI:10.1055/s-2007-983760

Reference yield:

Ethyl-<1>adamantyl-keton-oxim (26525-23-5) → 1-(1-adamantyl)propan-1-amine (60196-90-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00288a019

upstream raw materials:

Ethyl-<1>adamantyl-keton-oxim

1-adamantanecarbonitrile

ethyl iodide

1-iodoadamantane

Downstream raw materials:

[2,2]bipyridinyl

C₁₉H₂₇N

N-[1-(1-adamantyl)propyl]-2-bromoaniline

1-(adamantan-1-yl)propan-1-one