8-Methoxy-4-phenylquinoline

Base Information

• Chemical Name: 8-Methoxy-4-phenylquinoline
• CAS No.: 63352-82-9
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.285
• Mol file: 63352-82-9.mol

Synonyms:8-Methoxy-4-phenylquinoline

Chemical Property of 8-Methoxy-4-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Methoxy-4-phenylquinoline

There total 9 articles about 8-Methoxy-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-phenyl-1-(2-amino-3-methoxyphenyl)ethylene (189252-16-2) + Glyoxilic acid (298-12-4) → 8-Methoxy-4-phenylquinoline (63352-82-9)

Guidance literature:

With copper diacetate; In water; dimethyl sulfoxide; at 80 ℃; for 1.5h; Schlenk technique;

DOI:10.1016/j.tet.2020.131832

Reference yield: 78.0%

8-methoxy-4-phenyl-1,2,3,4-tetrahydroquinoline (1310708-11-2) → 8-Methoxy-4-phenylquinoline (63352-82-9)

Guidance literature:

With oxygen; sodium t-butanolate; In dimethyl sulfoxide; at 60 ℃; for 4h; under 760.051 Torr;

DOI:10.1021/acs.joc.9b03447

Reference yield: 76.0%

4-chloro-8-methoxyquinoline (16778-21-5) + phenylboronic acid (98-80-6) → 8-Methoxy-4-phenylquinoline (63352-82-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; benzene; for 48h; Heating;

DOI:10.1016/S0040-4020(01)80481-6

upstream raw materials:

4-chloro-8-methoxyquinoline

phenylboronic acid

2-methoxy-phenylamine

phenylacetylene

Refernces

• 1、 Cai, Hu,Tan, Wei,Xie, Yongfa,Yang, Ruchun,Yue, Shusheng. "DMSO/t-BuONa/O2-Mediated Aerobic Dehydrogenation of Saturated N-Heterocycles". . p. 7501 - 7509. Retrieved 2020/07/07.
• 2、 Karikomi, Michinori,Tsukada, Hiroshi,Toda, Takashi. "A new synthesis of 4-phenylquinolines by reaction of 2-(α-bromobenzyl)oxiranes with aniline derivatives". . p. 1249 - 1252. Retrieved 2007/10/03.