(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

Base Information

Chemical Name:(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate
CAS No.:1268671-83-5
Molecular Formula:C₂₇H₃₂O₄
Molecular Weight:420.549
Hs Code.:

Synonyms:(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

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Chemical Property of (1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

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Technology Process of (1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

There total 1 articles about (1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 72324-46-0
6-ethyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one

: 221099-71-4
exo-10,10-diphenyl-10-hydroxymethyl-7,7-dimethylbicyclo[2.2.1]heptane-2-ol

: 1268671-83-5
(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; for 6h; Reflux;
DOI:10.1016/j.tet.2010.12.009

Reference yield: 93.0%

: 123-75-1
pyrrolidine

: 1268671-83-5
(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

: 1268671-97-1
(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

Guidance literature:: With tert-butyl alcohol; In benzene; for 10h; Reflux;
DOI:10.1016/j.tet.2010.12.009

Reference yield:

: 1268671-83-5
(1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate

: 616207-71-7,518348-13-5
(3S,4R,5S)-prelactone B

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert-butyl alcohol / benzene / 10 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

2.2: 2 h / -78 - 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 22 h / 20 °C

4.1: 5% Pd(II)/C(eggshell); hydrogen / ethanol / 20 h / 760.05 Torr

With hydrogenchloride; 5% Pd(II)/C(eggshell); water; hydrogen; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran; ethanol; benzene;
DOI:10.1016/j.tet.2010.12.009