(R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione

Base Information

• Chemical Name: (R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione
• CAS No.: 959511-73-0
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.418
• Mol file: 959511-73-0.mol

Synonyms:(R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione

Chemical Property of (R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione

There total 1 articles about (R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-1-phenyl-4-morpholin-4-ylbut-2-ene-1,4-dione (78636-72-3) + 4-methoxyphenylboronic acid (5720-07-0) → (R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione (959511-73-0)

Guidance literature:

With triethylamine; [(S,S,R,R)-Duanphos)Rh(nbd)]BF₄; In tetrahydrofuran; water; at 65 ℃; for 16h;

DOI:10.1021/jo701682c

Reference yield: 80.0%

(R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione (959511-73-0) → (R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutan-1-one

Guidance literature:

With potassium fluoride; polymethylhydrosiloxane; palladium diacetate; In tetrahydrofuran; water; chlorobenzene; at 50 ℃; for 2h;

DOI:10.1021/jo701682c

Reference yield: 52.0%

(R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione (959511-73-0) + methylmagnesium bromide (75-16-1) → (R)-3-(4-methoxyphenyl)-1-phenylpentane-1,4-dione

Guidance literature:

(R)-2-(4-methoxyphenyl)-1-morpholin-4-yl-4-phenylbutane-1,4-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

methylmagnesium bromide; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jo701682c

upstream raw materials:

(E)-1-phenyl-4-morpholin-4-ylbut-2-ene-1,4-dione

4-methoxyphenylboronic acid