Chemical Property of L-cystathionine
Chemical Property:
- Appearance/Colour:White Crystalline Solid
- Melting Point:312
- Refractive Index:1.592
- Boiling Point:481 °C at 760 mmHg
- PKA:2.08±0.10(Predicted)
- Flash Point:244.7 °C
- PSA：151.94000
- Density:1.43 g/cm3
- LogP:0.33410
- Storage Temp.:−20°C
- Solubility.:Aqueous Acid (Slightly)
- XLogP3:-6
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:7
- Exact Mass:222.06742811
- Heavy Atom Count:14
- Complexity:212
- Purity/Quality:
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99% *data from raw suppliers
L-(+)-Cystathionine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Amino Acids and Derivatives
- Canonical SMILES:C(CSCC(C(=O)O)N)C(C(=O)O)N
- Isomeric SMILES:C(CSC[C@@H](C(=O)O)N)[C@@H](C(=O)O)N
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Description
L-(+)-Cystathionine is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine. L-(+)-Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such as cystathioninuria.
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Uses
Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine L-Cystathionine has been used in ultra-performance liquid chromatography for the validation of cystathionine and the correlation of its abundance with vertebrate metamorphosis. It has also been used as an inhibitor of sinusoidal GSH (glutathione) carrier to signify that thiol redox state imbalance is associated with the modulation of autophagy in carcinoma cells.
