3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Base Information

Chemical Name:3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide
CAS No.:1450919-85-3
Molecular Formula:C₂₃H₁₇F₃N₄O₃S₂
Molecular Weight:518.54
Hs Code.:

Synonyms:3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Chemical Property of 3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Technology Process of 3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

There total 8 articles about 3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₂₅F₃N₄O₄S₂

: 1450919-85-3
3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.333333h;

Reference yield:

: 2369-13-3
3-fluoro-4-nitroaniline

: 1450919-85-3
3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

1.2: 1 h / 25 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2.2: 0.25 h / -78 °C

3.1: sodium trimethylsilanolate / tetrahydrofuran / 0 °C

4.1: acetic acid; iron / tetrahydrofuran / 40 h / Sealed tube; Heating

5.1: caesium carbonate / acetonitrile / 2 h

6.1: trifluoroacetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h

7.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.17 h / 130 °C / Sealed tube

8.1: trifluoroacetic acid / dichloromethane / 0.33 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium trimethylsilanolate; sodium tris(acetoxy)borohydride; iron; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; sodium t-butanolate; sodium nitrite; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 86156-93-6
3-fluoro-4-nitrobenzene-1-sulfonyl chloride

: 1450919-85-3
3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 0.25 h / -78 °C

2.1: sodium trimethylsilanolate / tetrahydrofuran / 0 °C

3.1: acetic acid; iron / tetrahydrofuran / 40 h / Sealed tube; Heating

4.1: caesium carbonate / acetonitrile / 2 h

5.1: trifluoroacetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h

6.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.17 h / 130 °C / Sealed tube

7.1: trifluoroacetic acid / dichloromethane / 0.33 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium trimethylsilanolate; sodium tris(acetoxy)borohydride; iron; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; sodium t-butanolate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;